Previous studies have shown that self-antigens overexpressed in malignant tissue can provide a basis for a tumorspecific immune response. The mucin MUC2 is strongly overexpressed in all mucinous tumors of colon, breast, ovary and pancreas. In the corresponding normal tissue it is either not expresse
β¦ LIBER β¦
Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions
β Scribed by Lu, Y.-C.; Yao, X.; Crystal, J. S.; Li, Y. F.; El-Gamil, M.; Gross, C.; Davis, L.; Dudley, M. E.; Yang, J. C.; Samuels, Y.; Rosenberg, S. A.; Robbins, P. F.
- Book ID
- 125540872
- Publisher
- American Association for Cancer Research
- Year
- 2014
- Tongue
- English
- Weight
- 821 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1078-0432
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## Abstract Tumor immunity developing as a response to an autologous colonβtumor/bacillus CalmetteβGuerin (BCG) vaccine appears to be associated with induction of CD4 helper T cells, implied by the observation that vaccine efficacy is associated with major histocompatibility complex classβll molecu