Efficient gene transfer into hematopoietic cells by a retargeting adenoviral vector system with a chimeric fiber of adenovirus serotype 5 and 11p

Development of an adenoviral vector syst

Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells

✍ Marcus Nilsson; Johan Ljungberg; Johan Richter; Thomas Kiefer; Mattias Magnusson 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 245 KB

## Abstract ## Background A paucity of coxsackie adenovirus receptor (CAR) hampers the adenovirus serotype 5 (Ad5)‐based vector‐mediated gene transfer into malignant hematopoietic cells. Fiber‐retargeted adenoviral vectors with species B tropism can potentially bypass the CAR requirement and facil