Synthesis of enantiomeric diethyl (1R,2R
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Andrzej E. Wróblewski; Katarzyna B. Balcerzak
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Article
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1998
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Elsevier Science
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French
⚖ 540 KB
Addition of diethyl phosphite to 2,3-O-cyclohexylidene-D-glyceraldehyde catalyzed by triethylamine or fluorides led to ca. 35:65 mixtures of diethyl (IR,2R)-and (1S,2R)-2,3-O-cyclohexylidene-l,2,3trihydroxypropylphosphonates (4a) and (4b). Application of lithium diethylphosphonate only slightly impr