Efficient Entry into Medium-Ring Keto-Lactones. The Ruthenium Tetraoxide Promoted Oxidative Cleavage of β-Hydroxyethers.

✍ Scribed by Helena M. C. Ferraz; Luiz S. Jr. Longo

• Book ID: 101945272
• Publisher: John Wiley and Sons
• Year: 2003
• Weight: 97 KB
• Volume: 34
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.200333170

✦ Synopsis

Efficient Entry into Medium-Ring Keto-Lactones. The Ruthenium Tetraoxide Promoted Oxidative Cleavage of β-Hydroxyethers. -Ruthenium tetraoxide, in situ generated from NaIO4 and catalytic amounts of RuCl3, is described as an efficient reagent for the oxidative cleavage of bicyclic tetrahydrofuranols such as (I) to yield medium ring diketones (II). These products are interesting segments in natural compounds. -(