Efficient Enantioselective Synthesis of 3-Aminochroman Derivatives Through Ruthenium-Synphos Catalyzed Asymmetric Hydrogenation
✍ Scribed by Wu, Zi; Ayad, Tahar; Ratovelomanana-Vidal, Virginie
- Book ID
- 127083188
- Publisher
- American Chemical Society
- Year
- 2011
- Tongue
- English
- Weight
- 742 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1523-7060
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## Abstract Enantioselective syntheses of several paraconic acids have been achieved using catalyzed asymmetric hydrogenation of β‐keto esters with SYNPHOS^®^ as a ligand. This strategy allowed the short synthesis of biologically active (−)‐methylenolactocin **1**, (−)‐protolichesterinic acid **2**
## Abstract A new, optically active, atropisomeric diphosphane ligand, (2,3,2′,3′‐tetrahydro‐5,5′‐bi(1,4‐benzodioxin)‐6,6′‐diyl)bis‐(diphenylphosphane) (SYNPHOS^®^), has been synthesized, characterized, and used in ruthenium‐catalyzed asymmetric hydrogenations. This new ligand has been compared wit