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Efficient Discovery of Nonlinear Dependencies in a Combinatorial Catalyst Data Set.

✍ Scribed by James N. Cawse; Manfred Baerns; Martin Holena


Publisher
John Wiley and Sons
Year
2004
Weight
50 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract We have previously reported the design and synthesis of ligands that stabilize Transthyretin protein (TTR) in order to obtain therapeutically active compounds for Familial Amyloid Polyneuropathy (FAP). We are hereby reporting a drug design strategy to optimize these ligands and map them