Diastereoselective Darzens reactions of
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Shigeru Arai; Yukari Suzuki; Kazuyuki Tokumaru; Takayuki Shioiri
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Article
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2002
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Elsevier Science
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French
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The development of the highly diastereoselective catalytic synthesis of glycidic acid derivatives via Darzens reaction is described. The reaction of a-chloroesters and amides with aromatic aldehydes smoothly proceeds in the presence of a quaternary ammonium salt as a phase-transfer catalyst to give