Efficient coupling reactions of lithium alkynyl(triisopropoxy)borates with aryl halides: application to the antifungal terbinafine synthesis

✍ Scribed by Chang Ho Oh; Seung Hyun Jung

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 65 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01543-4

✦ Synopsis

Thermally stable lithium alkynyl(triisopropoxy)borates were reacted with several aryl halides in the presence of palladium catalysts to give the corresponding cross-coupling products in excellent yields. The present methodology has been successfully applied to the antifungal terbinafine synthesis.