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Efficient Copper-Catalyzed Synthesis of Poly-N-Heterocycles Containing Amino Acid Residues

✍ Scribed by Tao Liu; Prof. Dr. Ruji Wang; Haijun Yang; Prof. Dr. Hua Fu

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 313 KB
Volume: 17
Category: Article
ISSN: 0947-6539
DOI: 10.1002/chem.201100690

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✦ Synopsis

Abstract

An efficient copper‐catalyzed method has been developed for the synthesis of poly‐N‐heterocycles containing amino acid residues. The protocol uses readily available 2‐halobenzamides containing amino acids and their methyl esters, substituted phenylacetonitriles, and malononitrile as the starting materials and the reactions were performed well under mild conditions. The method should provide a novel and useful strategy for synthesis of N‐heterocyclic compounds.

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