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Efficient Conversion of Esters to α-Trimethylsilylketones. Preliminary communication

✍ Scribed by Martin Demuth

Publisher
John Wiley and Sons
Year
1978
Tongue
German
Weight
146 KB
Volume
61
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Secondary and tertiary carboxylic methyl or ethyl esters (2a‐c) were converted with trimethylslylmethyllithium (3a‐c) in high yields. Under identical reaction conditions the primary esters 2d,e gave 3d, e in lower yields. Since the trimethylsilyl (TMS) group α to a ketone is known to undergo facile elimination under a variety of reaction conditions, the method also constitutes a highly versatile ester to methylketone sequence.

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