Efficient construction of bicyclic systems by an internal SN2′ enolate alkylation/ring-closing metathesis (RCM) strategy: a concise synthesis of the trans-hydrindane nucleus

✍ Scribed by Hyunil Jo; Jongkook Lee; Hyoungsu Kim; Sanghee Kim; Deukjoon Kim

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 135 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01780-5

✦ Synopsis

A concise and efficient synthesis of the trans-hydrindane system has been achieved by a novel intramolecular S N 2% enolate alkylation/ring-closing metathesis (RCM) strategy with a good degree of stereocontrol.