๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Efficient co-crystal screening using solution-mediated phase transformation

โœ Scribed by Geoff G.Z. Zhang; Rodger F. Henry; Thomas B. Borchardt; Xiaochun Lou

Book ID
102398155
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
147 KB
Volume
96
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

โœฆ Synopsis

We have extended the established physical stability treatment for hydrates/ solvates to co-crystals with solid co-crystal formers. Based on the proposed treatment, a suspension/slurry screening technique is developed and tested in sixteen pharmaceutical co-crystal systems with success. The theoretical treatment and the practical screening technique should benefit the researchers in the field of co-crystallization in improving the screening efficiency.

๐Ÿ“œ SIMILAR VOLUMES

Stable-form screening: Overcoming trace
Stable-form screening: Overcoming trace impurities that inhibit solution-mediated phase transformation to the stable polymorph of sulfamerazine
โœ Yuchuan Gong; Benjamin M. Collman; Shawn M. Mehrens; Enxian Lu; Jonathan M. Mill ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 298 KB

Solution-mediated phase transformation (SMPT) has been used as a focused technique to rapidly identify the stable polymorph of a given substance. Despite ample precedence for acetonitrile being a good solvent for SMPT of sulfamerazine (SMZ), samples from specific lots of SMZ failed to convert from F