Efficient asymmetric synthesis of a functionalized Δ2-pyrazoline

✍ Scribed by Olivia Poupardin; Christine Greck; Jean Pierre Genet*

• Book ID: 104211131
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 56 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01582-3

✦ Synopsis

The first asymmetric synthesis of the (4S,5R)-5-carbomethoxy-4-hydroxy-D 2 -pyrazoline in four steps is described starting from the methyl 4,4-dimethoxy-3-oxobutanoate by sequential catalytic hydrogenation and electrophilic amination.