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Efficient Association Mapping of Quantitative Trait Loci with Selective Genotyping

✍ Scribed by B.E. Huang; D.Y. Lin

Book ID
117855008
Publisher
American Society of Human Genetics
Year
2007
Tongue
English
Weight
226 KB
Volume
80
Category
Article
ISSN
0002-9297

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## Abstract Huang and Lin ([2007] Am J Hum Genet 80:567–572) proposed a conditional‐likelihood approach for mapping quantitative trait loci (QTL) under selective genotyping, and demonstrated via simulation that their model tends to be more powerful than the prospective linear regression. However, w

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Sib pairs were selectively sampled for extreme concordance or discordance for the quantitative trait Q1, a simulated phenotype (GAW10). Two selective sampling criteria were used (SC1 and SC2), and results for these were compared to linkage analyses using all pairs (ALL). In total 773 sib pairs were