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Efficient Approximation of P-value of the Maximum of Correlated Tests, with Applications to Genome-Wide Association Studies

✍ Scribed by Qizhai Li; Gang Zheng; Zhaohai Li; Kai Yu

Book ID: 111111422
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 353 KB
Volume: 72
Category: Article
ISSN: 0003-4800
DOI: 10.1111/j.1469-1809.2008.00437.x

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## Abstract Genome‐wide association (GWA) studies have proved extremely successful in identifying novel genetic loci contributing effects to complex human diseases. In doing so, they have highlighted the fact that many potential loci of modest effect remain undetected, partly due to the need for sa