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Efficient and Practical Synthesis of Both Enantiomers of 3-Phenylcyclopentanol Derivatives.

โœ Scribed by Yoshiyuki Okumura; Akemi Ando; William Stevens; Makoto Shimizu


Publisher
John Wiley and Sons
Year
2003
Weight
138 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis of Both Enantiomers of Flavano
โœ Yoshihiro Noda; Morio Watanabe ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 85 KB

Seebach on the occasion of his 65th birthday An efficient enantiospecific synthesis of the (R)-and (S)-enantiomers of flavanone and 2-methylchromanone is described. The key steps are a C,C-bond formation by ring opening of a chiral epoxide with a dithiane anion, followed by a Mitsunobu cyclization.