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Efficient and practical syntheses of a stable labelled form of the non-narcotic analgesic, bicifadine and its metabolites

✍ Scribed by Zhengming Chen; Ji Yang; Gillian Little; Andrew Keats

Book ID: 102367971
Publisher: John Wiley and Sons
Year: 2007
Tongue: French
Weight: 130 KB
Volume: 50
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1171

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✦ Synopsis

Abstract

An efficient and practical synthesis of deuterium‐labelled bicifadine, together with 3 deuterium‐labelled bicifadine metabolites, was developed. The levels of deuterium incorporation are high, and the products were used as internal standards in bioanalytical method development and clinical bioanalysis. Copyright © 2007 John Wiley & Sons, Ltd.

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