Efficient and clean synthesis of N-alkyl carbamates by transcarboxylation and O-alkylation coupled reactions using a DBU–CO2 zwitterionic carbamic complex in aprotic polar media

✍ Scribed by Eduardo R Pérez; Michele Odnicki da Silva; Vanessa C Costa; Ubirajara P Rodrigues-Filho; Douglas W Franco

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 107 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00697-4

✦ Synopsis

N-Alkyl carbamates were obtained with good to excellent yields by clean and mild transcarboxylation of several amines with the previously synthesized DBU-CO 2 complex and subsequent O-alkylation. Transcarboxylation was found to be selective, as only carbamate was formed from 1-hydroxy-2-aminobutanol.