✦ LIBER ✦

Efficient alternative for the reduction of N-trichloroacetyl groups in synthetic chondroitin oligosaccharide intermediates

✍ Scribed by Aude Vibert; Chrystel Lopin-Bon; Jean-Claude Jacquinet

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 860 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.02.005

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✦ Synopsis

An efficient alternative for the reduction of N-trichloroacetyl groups in chondroitin oligosaccharides is reported. It involves the use of Zn-Cu couple in acetic acid, and was successfully applied to a large panel of synthetic intermediates useful for the preparation of chondroitin oligomers, a class of natural products with numerous relevant biological functions.