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Efficiency of the Pioneer Round of Translation Affects the Cellular Site of Nonsense-Mediated mRNA Decay

✍ Scribed by Hanae Sato; Nao Hosoda; Lynne E. Maquat


Book ID
116754510
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
810 KB
Volume
29
Category
Article
ISSN
1097-2765

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## Abstract Nonsense‐mediated mRNA decay (NMD) is an mRNA surveillance system that eliminates aberrant mRNAs containing premature translation termination codons (PTCs). We evaluated the role of NMD in of Ullrich's disease. The patient has a frameshift mutation with a PTC in the collagen VI Ξ±2 gene