## Abstract Medulloblastoma is the most common malignant central nervous system tumor of childhood and can occur sporadically or in association with inherited cancer susceptibility syndromes such as the nevoid basal cell carcinoma syndrome (NBCCS). To determine whether an association existed betwee
Efficiency of Synthetic Retrospective Studies
β Scribed by Alice S. Whittemore
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 307 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0323-3847
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
In many large cohort studies of association between a disease and a concommitant variable, only a small fraction of subjects develope the disease. Substantial computational expense can be avoided by restricting the analysis to the diseased cases and a random sample of diseaseβfree controls. This paper examines the efficiency of such synthetic retrospective designs relative to that of the full cohort analysis when the association is studied using the logistic or proportional hazards model. Within this context the efficiencies of matched vs. unmatched designs are also examined.
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