Efficiency of Fatty Acids as Chemical Penetration Enhancers: Mechanisms and Structure Enhancement Relationship
β Scribed by Sarah A. Ibrahim; S. Kevin Li
- Book ID
- 106493864
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 224 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
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Nine azacycloalkanone (5-, 6-, or 7-member ring) derivatives with an alkyl or alkenyl (terpene) chain (10, 15, or 20 carbons) were compared with 1-dodecylazacycloheptan-2-one (azone, 1) for their effects on the percutaneous penetration of 6-mercaptopurine (6-MP) through excised guinea pig skin. Pret
Chemical penetration enhancers are widely used in transdermal pharmaceuticals as well as cosmetic products. Selection of suitable enhancers in topical formulations requires an understanding of the mechanism of action of these enhancers. The objective of the present study was to evaluate the enhancem