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Efficiency of a composite treatment for mixed fission products in rats

✍ Scribed by Krista Kostial; Biserka Kargačin; Ivan Šimonović


Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
495 KB
Volume
3
Category
Article
ISSN
0260-437X

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✦ Synopsis


The effect of a composite antidotal treatmentconsisting of a mixture of calcium alginate, ferrihexacyanoferrate(l1) and potassium iodide -administered in diet and/or Na3(CaDTPA) administered intraperitoneally on the absorption and the removal of radioactive strontium, caesium, iodine and cerium was investigated in 7-week-old female rats. The animals were on respective treatments for 3 days. The retention of 141Ce, "Sr, 137Cs and 1311 was determined in the whole body, carcass, gut, liver, kidneys and respective critical organs (femur, muscle, thyroid) 6 days after their oral or intraperitoneal administration. In animals which received the antidotal mixture or Na3(CaDTPA) alone, the radionuclide retention was practically the same as in rats which were given the composite treatment [mixture + Na3(CaDTPA)]. This indicates that the efficiency of one treatment was not increased by the other. For 141Ce, Na3(CaDTPA) was an effective antidote, while "Sr, 137Cs and 1311 were reduced by the mixture. It is concluded that the composite treatment might be a quick treatment for choice for reducing mixed fission products retention, especially in cases when identification of exposure is difficult or impossible to make.


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