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Efficacy of venlafaxine treatment in depressed patients with psychomotor retardation or agitation: A metaanalysis

✍ Scribed by R. Entsuah; G. V. Upton; R. Rudolph

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 473 KB
Volume: 10
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470100305

No coin nor oath required. For personal study only.

✦ Synopsis

A meta-analysis was performed to assess the effectiveness of the novel antidepressant venlafaxine in depressed patients with psychomotor retardation andor agitation [respective baseline item score greater than zero on the Hamilton Rating Scale for Depression (HAM-D)]. Data from five comparable placebo-controlled double-blind studies (n = 1 122) were analysed; in two of them venlafaxine was also compared with imipramine. Separate analyses were performed on data from psychomotor retarded and agitated patients by using a one-way analysis of covariance (HAM-D total score during therapy, dependent variable; baseline HAM-D total score, covariate; therapy, factor). The overall pool of venlafaxine-treated patients showed a significantly greater decline in total HAM-D score than did the placebo-treated patients. Venlafaxine-treated patients with retardation showed a significantly greater decline in total HAM-D scores than did placebo-and imipramine-treated patients, starting at weeks 3 and 4, respectively. Venlafaxine-treated patients with agitation showed a significantly greater decline in total HAM-D scores than did placebo-and imipramine-treated patients, starting at weeks 2 and 1, respectively. In conclusion, venlafaxine is effective in depressed patients whether or not they have symptoms of psychomotor retardation or agitation.

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