Efficacy of prolonged interferon therapy for patients with chronic hepatitis C with HCV-genotype 1b and high virus load
β Scribed by Yasuji Arase; Kenji Ikeda; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Mariko Kobayashi; Fumitaka Suzuki; Norio Akuta; Takashi Someya; Hiromitsu Kumada
- Publisher
- Springer Japan
- Year
- 2003
- Tongue
- English
- Weight
- 163 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0944-1174
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In patients with chronic hepatitis C, the influence of the genetic heterogeneity of the hepatitis C virus (HCV) on the progression of liver disease and on the responsiveness to interferon therapy is a matter of controversy. In this study we evaluated the genetic complexity of HCV by singlestrand con
## Abstract Patients with high viral load (β₯1.0βΓβ10^5^ IU/ml) of hepatitis C virus (HCV) genotype 1b do not achieve high sustained virological response rates to interferon (IFN)/ribavirin combination therapy. Previous studies suggested that pretreatment amino acid (aa) substitution patterns in the