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Efficacy of polyanionic collagen matrices for bone defect healing

✍ Scribed by Rocha, Lenaldo B. ;Brochi, Marco Aur�lio C. ;Bellucci, �ngela D. ;Rossi, Marcos A.

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
290 KB
Volume
71B
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

Polyanionic collagen–elastin matrices (PCEMs) possess attractive properties, such as extra negative charges, piezoelectricity, and extra RGD sites, which could make them effective in the treatment of bone defects. Although they are biocompatible with the osteogenesis process, it is unknown if PCEMs could aid in the recovery of bone defects in challenging situations. To evaluate this hypothesis, three PCEMs, differing in their negative charge density, were implanted in rat calvarial defects. Specimens harvested at 3, 7, 15, 30, and 60 days after implantation were evaluated radiographically and histologically. Two matrices were able to sustain the osteogenesis process and quickly recover the lost bone structure. The third, and most electronegative, left matrix remnants amidst the areas of new bone. The control showed bone formation limited to the boundaries of the defect. These results suggest that some PCEMs might become a useful resource in the treatment of bone defects. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 71B: 355–359, 2004

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