Efficacy of polyadenylic.polyuridylic acid in the treatment of chronic active hepatitis B
β Scribed by Ki Baik Hahm; Kwang Hyub Han; Won Ho Kim; Dae Soon Yim; Chae Yoon Chon; Young Myung Moon; Jin Kyung Kang; In Suh Park; Jung Koo Youn; Evelyne Deschamps de Paillette
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 626 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0192-0561
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During brief exposure to trichloroacetic acid at 0 degree C, significant amounts of tritiated polyuridylic acid are converted to acid-soluble products. The loss of polymeric radioactivity is dependent on both acid concentration and the time of exposure to acid. When trichloroacetic acid precipitatio
## Abstract Hepatitis B e antigen (HBeAg)βnegative chronic hepatitis B results from infection with hepatitis B virus mutants unable to produce HBeAg. It accounts for 7β30% of patients with chronic hepatitis B virus (HBV) worldwide, with the highest rates reported for Mediterranean Europe and Asia.
Treatment of 171 patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) with adefovir dipivoxil (ADV) 10 mg over 48 weeks resulted in significant histological, virological, serological, and biochemical improvement compared with placebo. The long-term efficacy and safety of AD