Efficacy of pegylated interferon plus ribavirin combination therapy for hepatitis C patients with normal ALT levels: a matched case–control study
✍ Scribed by Naoki Hiramatsu; Yuko Inoue; Tsugiko Oze; Nao Kurashige; Takayuki Yakushijin; Kiyoshi Mochizuki; Takuya Miyagi; Tomohide Tatsumi; Shinichi Kiso; Tatsuya Kanto; Akinori Kasahara; Tetsuo Takehara; Masahide Oshita; Eiji Mita; Hideki Hagiwara; Yoshiaki Inui; Kazuhiro Katayama; Shinji Tamura; Harumasa Yoshihara; Yasuharu Imai; Norio Hayashi
- Publisher
- Springer Japan
- Year
- 2011
- Tongue
- English
- Weight
- 209 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0944-1174
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## Abstract The efficacy of interferon (IFN) monotherapy for non‐responders to pegylated interferon (PEG‐IFN) plus ribavirin (RBV) combination therapy is still unclear. To evaluate the impact of IFN monotherapy on biochemical response, 200 consecutive patients infected with HCV genotype 1b, who rec
## Abstract Substitution of amino acid (aa) 70 and 91 in the core region of HCV genotype 1b is a useful pretreatment predictor of efficacy of 48‐week peginterferon (PEG‐IFN) plus ribavirin (RBV) therapy. Here, we determined the efficacy of 72‐week PEG‐IFN/RBV and the predictive factors to such ther