Clinical efficacy of methadone in patien
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James C. Crews; Nancy J. Sweeney; Donald D. Denson
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Article
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1993
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John Wiley and Sons
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English
โ 751 KB
Background. Development of tolerance to opioid analgesics occurs often in patients with cancer-related pain. Cross-tolerance among opioid analgesics provides the physician with a major management problem. Incomplete cross-tolerance among opioid analgesics has been demonstrated to occur in animals an