Efficacy of mycobacterial components in the immunotherapy of mice with pulmonary tumor deposits

✍ Scribed by S. Sukumar; J. T. Hunter; E. Yarkoni; H. J. Rapp; B. Zbar; E. Lederer

• Book ID: 104660505
• Publisher: Springer-Verlag
• Year: 1981
• Tongue: English
• Weight: 502 KB
• Volume: 11
• Category: Article
• ISSN: 0340-7004
• DOI: 10.1007/bf00199263

✦ Synopsis

The effectiveness of each of two mycobacterial components and a synthetic analog of one of them in the eradication of pulmonary deposits of intravenously injected syngeneic fibrosarcoma 1023 in C3H mice was studied. BCG cell walls (BCG CW), trehalose 6, 6'-dimycolate (TDM) or 6, 6'-di-O-2-tetradecyl, 3-hydroxyoctadecanoyl-a,a-trehalose (C76), a synthetic analog of TDM, was administered in emulsified form by three different routes: intraperitoneal, intradermal, or intravenous, 24 h after intravenous injection of 1023 tumor cells. The most effective form of therapy was TDM given by the intraperitoneal route; about 50% of treated animals were cured. Higher doses of BCG CW or C76 also led to a significant number of cures. Each agent caused a significant prolongation of survival time of the treated mice at two or more of the dosages tested; however, their routes of optimal activity varied.