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Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease

✍ Scribed by J. M. Rabey; P. Nissipeanu; A. D. Korczyn

Publisher
Springer
Year
1992
Tongue
English
Weight
363 KB
Volume
4
Category
Article
ISSN
1435-1463

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There is increasing evidence for the involvement of glutamate-mediated neurotoxicity in the pathogenesis of Alzheimer's disease (AD). We suggest that glutamate receptors of the N-methyl-D-aspartate (NMDA) type are overactivated in a tonic rather than a phasic manner in this disorder. This continuous