This placebo controlled, double-blind study evaluated the efficacy and safety of lamivudine in patients with hepatitis B e antigen (HBeAg)-negative/hepatitis B virus (HBV) DNA-positive chronic hepatitis B. Patients were randomized to receive 100 mg lamivudine orally once daily for 52 weeks (n ؍ 60
Efficacy of lamivudine treatment in Japanese patients with hepatitis B virus-related cirrhosis
✍ Scribed by Hiromi Ooga; Fumitaka Suzuki; Akihito Tsubota; Yasuji Arase; Yoshiyuki Suzuki; Norio Akuta; Hitomi Sezaki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Kenji Ikeda; Mariko Kobayashi; Marie Matsuda; Junko Satoh; Hiromitsu Kumada
- Publisher
- Springer Japan
- Year
- 2004
- Tongue
- English
- Weight
- 227 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0944-1174
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## Abstract The aim of this study was to elucidate the long‐term outcome after interferon (IFN) or lamivudine (LMV) treatment in Japanese patients with hepatitis B e antigen (HBeAg) positive chronic hepatitis B. Inclusion criteria were biopsy proven chronic hepatitis or liver cirrhosis, no history
Key Points 1. Hepatitis B virus replication is associated with a severe outcome in patients with decompensated cirrhosis. 2. Viral suppression induced by antivirals results in a clinical improvement that allows liver transplantation to be delayed or avoided. 3. Early treatment intervention is mandat
Lamivudine is an effective antiviral agent for the treatment of chronic type B hepatitis. Recent studies have shown the appearance of lamivudine resistant viruses with mutations at the tyrosine-methionine-aspartate-aspartate (YMDD) motif of the viral polymerase in hepatitis B virus (HBV) infected pa