Chlorpheniramine, a histamine HI receptor antagonist, reverses chloroquine resistance in Plasmodium falciaarum in vitro. However. the clinical sianificance of this remains unclear. We have evaluated the efficacv of chloroquine and a chloroquine-chlorbheniramine combination in 112 consecutive childre
Efficacy of FansidarsR for acute uncomplicated malaria due to Plasmodium falciparum in Colombia
โ Scribed by J. Soto; R. Martinez; G. Fonschiffrey; J. Dember
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 116 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0035-9203
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In the face of growing chloroquine resistance of Plasmodium falciparum, efforts to prolong the clinical usefulness of the drug have partly concentrated on its combination with potential resistance-reversing compounds. However, clinical studies on such combinations have been limited. We have compared
The efficacy of pyrimethamineisulfadoxine (I'S) and chloroquine plus chlorpheniramine, a histamine H1 receptor blocker which reverses chloroquine insensitivity in Plasmodium falciparum in vitro, was evaluated in 100 consecutive children with acute symptomatic uncomplicated falciparum malaria. Parasi