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Efficacy of Eight Experimental Bispyridinium Oximes Against Paraoxon-Induced Mortality: Comparison with the Conventional Oximes Pralidoxime and Obidoxime

✍ Scribed by S. M. Nurulain; D. E. Lorke; M. Y. Hasan; M. Shafiullah; K. Kuča; K. Musilek; G. A. Petroianu

Book ID
107678008
Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
311 KB
Volume
16
Category
Article
ISSN
1029-8428

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✍ D. E. Lorke; S. M. Nurulain; M. Y. Hasan; K. Kuča; K. Musilek; G. A. Petroianu 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 208 KB

In search for more efficacious reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus compounds, experimental K-oximes have been synthesized which show good in vitro efficacy. However, AChE inhibition by oximes themselves (as quantified by their intrinsic IC50) is the major cause