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Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model

✍ Scribed by Ruifang Mi; Jianhui Ma; Dechang Zhang; Limin Li; Hongbing Zhang


Book ID
118651228
Publisher
Elsevier
Year
2009
Tongue
Chinese
Weight
310 KB
Volume
36
Category
Article
ISSN
1673-8527

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## Abstract Tuberous sclerosis complex (TSC) is a familial tumor syndrome characterized by the development of hamartomas in the brain, heart, kidney, and skin. Disease‐causing mutations in the __TSC1__ or __TSC2__ gene result in constitutive activation of the highly conserved mTOR signal transducti