Efficacy of cationic liposome-mediated gene transfer to mesangial cells in vitro and in vivo
✍ Scribed by Henning Madry; Regina Reszka; Jürgen Bohlender; Jürgen Wagner
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 74 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0946-2716
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The lack of a small animal model of hepatitis C virus (HCV) infection has impeded elucidation of the pathogenesis of HCV. The aim of this study was to develop an HCV-expressing animal model by means of cationic liposome-mediated in uiuo gene transfer. To examine the feasibility of this strategy, pAc
## Abstract ## Background Inclusion of positively charged polymers such as protamine in adenovector formulations has been reported to improve the efficiency of adenovirus‐mediated gene transfer __in vitro__ and __in vivo.__ On the other hand, corticosteroids are known to inhibit inflammation and t