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Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial

✍ Scribed by Lorenz von Seidlein; Paul Milligan; Margaret Pinder; Kalifa Bojang; Chukwudi Anyalebechi; Roland Gosling; Rosalind Coleman; Justin Ifeanyichukwu Ude; Abubakar Sadiq; Manoj Duraisingh; David Warhurst; Ali Alloueche; Geoffrey Targett; Keith McAdam; Brian Greenwood; Gijs Walraven; Piero Olliaro; Tom Doherty


Book ID
117313059
Publisher
The Lancet
Year
2000
Tongue
English
Weight
97 KB
Volume
355
Category
Article
ISSN
0140-6736

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Artemisinin derivatives, such as artesunate, have a short half-life and very rapid anti-malarial activity. Theoretically, using such agents in conjunction with well-established anti-malarial drugs such as sulfadoxine-pyrimethamine may reduce the rate of drug resistance. Such a combination has not pr