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Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential

✍ Scribed by Hiroyuki Konno; Tatsuo Tanaka; Toshikazu Kanai; Keiji Maruyama; Satoshi Nakamura; Shozo Baba


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
483 KB
Volume
77
Category
Article
ISSN
0008-543X

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✦ Synopsis


BACKGROUND.

The summation of gene mutations increases the metastatic potential of colorectal cancer. The genetic characterization and hepatic metastatic potential of five xenotransplanted human colon carcinoma strains were investigated. Furthermore, the therapeutic effect of the angiogenesis inhibitor, TNP-470, was evaluated.