## Abstract ## BACKGROUND Caspofungin (CAS) as salvage therapy for refractory invasive aspergillosis (IA) had a response rate of 45% among a heterogeneous group of patients. The use of CAS with other agents is appealing given its unique mechanism of action. Therefore, the authors retrospectively e
Efficacy of amphotericin B or amphotericin B–intralipid in combination with caspofungin against experimental aspergillosis
✍ Scribed by Edward Sionov; Sonia Mendlovic; Esther Segal
- Book ID
- 108174374
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 555 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0163-4453
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The purpose of this study was to assess the antifungal activity and renal and hepatic toxicity of amphotericin B lipid complex (ABLC; Abelcet 1 ) following coadministration of Caspofungin to rats infected with Aspergillus fumigatus. Aspergillus fumigatus inoculum (1.3-2.3 Â 10 7 colony forming units
## Abstract ## BACKGROUND. Invasive aspergillosis (IA) has a poor prognosis in immunocompromised patients. Combinations of drugs that act on different targets are expected to improve the clinical efficacy of separate compounds. ## METHODS. Patients with proven or probable IA were randomized in a