Efficacy of a vancomycin solution to prevent bacteremia associated with an indwelling central venous catheter in neutropenic and non-Neutropenic cancer patients
✍ Scribed by Barriga, Francisco J.; Varas, Monica; Potin, Marcela; Sapunar, Francisco; Rojo, Hector; Martinez, Alejandro; Capdeville, Veronica; Becker, Ana; Vial, Pablo A.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 43 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
We evaluated the efficacy of a vancomycin 61 HepVan). Forty-four episodes of bacteremia solution in the prevention of bacteremia caused occurred, 23 of them due to VSO (16 occurred by vancomycin-sensitive organisms (VSO) in in the Hep group and 7 in the HepVan group cancer patients with a tunneled central venous (P ϭ 0.19). VSO bacteremia occurred in 14 neucatheter (CVC). Eighty-three patients who had tropenic (absolute neutrophil count Ͻ 500 ϫ a single lumen CVC were randomized to use a 10 9 /l) episodes (7 Hep vs. 7 HepVan) and in 9 heparin solution (25 U/ml) for daily catheter non-neutropenic episodes (9 Hep vs. 0 HepVan; flush with (HepVan) or without (Hep) vancomy-P ϭ 0.013). Vancomycin effectively prevented cin, 25 mcg/ml. Febrile episodes were recorded, bacteremia by VSO in non-neutropenic patients, and central and peripheral blood cultures were supporting the idea that intraluminal colonidrawn before beginning antibiotic therapy. Pa-zation of indwelling CVCs contributes to bactients participated in follow-up for 16,677 cathe-teremia only in these patients.