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Efficacy of a murine-p75-saporin immunotoxin for selective lesions of basal forebrain cholinergic neurons in mice

✍ Scribed by Nupur Nag; Mark G. Baxter; Joanne E. Berger-Sweeney


Book ID
116771109
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
844 KB
Volume
452
Category
Article
ISSN
0304-3940

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## Abstract The selective lesion of basal forebrain cholinergic neurons (BFCNs) is an unestimable tool to study the implication of these neurons in cognition, an interest widely motivated by their degeneration in Alzheimer's disease. Here we evaluated the histochemical and behavioral effects of a s