Efficacy is a contributing factor to the clinical onset of bronchodilation of inhaled β2-adrenoceptor agonists

A physical properties based approach for

A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of β2-adrenoceptor agonists as inhaled long-acting bronchodilators

✍ David Beattie; Michelle Bradley; Andrew Brearley; Steven J. Charlton; Bernard M. 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 630 KB

The chiral synthesis of a 4-hydroxybenzothiazolone based series of b 2 -adrenoceptor agonists is described. Using this methodology a library of N-substituted analogues were prepared for the rapid identification of leads with the potential to be fast onset and long-acting inhaled bronchodilators with