Efficacy and tolerability of vindesine in the treatment of small-cell lung cancer
β Scribed by D. A. L. Morgan
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 134 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0344-5704
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β¦ Synopsis
Eighteen patients suffering from small-cell lung cancer, all with measurable lesions, were treated with vindesine (3 mg/m2 i.v. on days 1 and 8 of a 21-day cycle). Partial responses (PR) were seen in six patients (three of whom had been previously heavily treated). Most patients tolerated the drug extremely well, an important consideration when expected cure rates are very poor.
π SIMILAR VOLUMES
Twenty-nine patients with non-small cell lung cancer refractory to prior therapy were treated with either vindesine (VDS) alone (3 mg/m2 every week) or the combination of VDS plus cisplatin (DDP) (100 mg/m2 every 28 days). Serial blood and urine samples were collected to assess the pharmacokinetics