Efficacy and safety of peripheral blood stem cell collection in elderly donors; does age interfere?

✍ Scribed by Daniel Lysák; Zdeněk Kořístek; Zdeňka Gašová; Iva Skoumalová; Pavel Jindra

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 266 KB
• Volume: 26
• Category: Article
• ISSN: 0733-2459
• DOI: 10.1002/jca.20269

✦ Synopsis

Elderly patients with hematological malignancies are often reliant on allogeneic transplantations. Older family relatives are increasingly involved in utilization as PBSC donors. We analyzed the mobilization results from 103 donors of age 55 years in comparison with 121 younger donors of age <55 years. The median CD341 count in peripheral blood on day 15 of the mobilization was higher in younger than in older donor group (72.0 vs. 37.0 cells/lL, P < 0.0001). Linear regression showed a negative correlation between the age and CD341 count in peripheral blood (P < 0.0001) and apheresis product (P < 0.0001). Based on multivariate analysis, the amount of circulating CD341 cells appeared to be negatively influenced by age (P < 0.001) and positively by the preapheresis WBC count (P < 0.001). The precollection CD341 (P < 0.0001), PLT (P 5 0.0144) counts, and age (P 5 0.0392) were confirmed as independent factors determining the collection yield. The side effects of G-CSF administration were similar in both the groups. Apheresis complications were more frequently recorded in elderly donors (29 vs. 15%, P 5 0.0096). Higher age represents a risk factor for poorer mobilization results. A requirement for more than one apheresis in older donors occurs more frequently to obtain the adequate amount of CD341 cells. Mobilization and collection procedures are associated with acceptable risks and complication rates in elderly donors.