Effects on visual acuity of neonatal or adult tectal ablation in rats
โ Scribed by A. Cowey; D. B. Henken; V. H. Perry
- Publisher
- Springer-Verlag
- Year
- 1982
- Tongue
- English
- Weight
- 370 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0014-4819
No coin nor oath required. For personal study only.
โฆ Synopsis
Tectal ablation in neonatal rats leads to retrograde degeneration of retinal ganglion cells whereas similar damage in adults does not. We show here that the behavioral effects are comparably different. When rats with neonatal tectal ablation are tested as adults they are impaired in learning a discrimination between vertical and horizontal stripes and their visual acuity for square-wave gratings is slightly but significantly reduced.
๐ SIMILAR VOLUMES
Pregnant rats were treated for five consecutive days during gestation with s.c. injections of the ornithine decarboxylase (ODC) inhibitor alpha-difluoromethylornithine (DFMO). Treatment beginning at gestational days 13 or 14 was effective in inhibiting ODC and altering polyamine levels, and resulted