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Effects on prostanoid formation and pharmacokinetics of dazmegrel (UK-38,485), a novel thromboxane synthase inhibitor, in man

โœ Scribed by Reinhard L. Lorenz; Sven Fischer; Wolfgang Wober; Helmut A. Wagner; Peter C. Weber


Book ID
115778898
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
652 KB
Volume
35
Category
Article
ISSN
0006-2952

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The pharmacokinetics and pharmacologic effects of a potent, selective inhibitor of thromboxane synthetase, CV-4151 [(E)-7-phenyl-7-(3-pyridyl)-6-heptenoic acid] on prostanoid formation and platelet aggregation were studied in 42 healthy male volunteers. The drug was well tolerated. After oral admini