Effects of Δ9-tetrahydrocannabinol, (R)-methanandamide, SR 141716, and d-amphetamine before and during daily Δ9-tetrahydrocannabinol dosing
✍ Scribed by Richard J Lamb; Torbjörn U.C Järbe; Alexandros Makriyannis; Sonyan Lin; Andreas Goutopoulos
- Book ID
- 114013086
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 209 KB
- Volume
- 398
- Category
- Article
- ISSN
- 0014-2999
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The onset and duration of tolerance to three effects of A9-tetrahydrocannabinol (A9-THC) given orally to mice were compared. The effects of A9-THC studied were: hypothermia, the depression of intestinal motility and the effect on spontaneous locomotor activity. When mice were dosed and tested at 24
The development of tolerance to delat9-tetrahydrocannabinol (delta9-THC) was examined. Rats with permanently indwelling intravenous catheters were injected daily with delta9-THC, 2 mg/kg, for up to 10 days and on each day subjective behaviour and body weight of each rat were noted. Tolerance appeare