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Effects of β-funaltrexamine on dose–effect curves for heroin self-administration in rats: comparison with alteration of [3H]DAMGO binding to rat brain sections

✍ Scribed by Thomas J. Martin; M.Graziella DeMontis; Susy A. Kim; Glen M. Sizemore; Steven I. Dworkin; James E. Smith


Book ID
117512570
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
162 KB
Volume
52
Category
Article
ISSN
0376-8716

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Intracerebroventricular administration of beta-funaltrexamine (beta-FNA) reduces the density of mu opioid receptors as measured by in situ autoradiography by 40-50% throughout the brain, with little regional variation [Martin et al. (1993) J. Pharmacol. Exp. Ther. 267:506-514] Recently an assay has