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Effects of β- and γ-carboline derivatives on DNA topoisomerase activities

✍ Scribed by Yasunori Funayama; Kazuto Nishio; Keiji Wakabayashi; Minako Nagao; Kayoko Shimoi; Tatsuo Ohira; Shizuo Hasegawa; Nagahiro Saijo


Book ID
113194849
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
777 KB
Volume
349
Category
Article
ISSN
0027-5107

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## Abstract magnified image A series of unreported chiral β‐carbolines **4** with trifluoromethyl group at position‐1 and chiral carboxamide chains or amino acid ester chains at position‐3 has been designed and synthesized. The results of bioassay __in vitro__ show that compounds **4e, 4i** and **