Effects of α-Synuclein Immunization in a Mouse Model of Parkinson’s Disease
✍ Scribed by Eliezer Masliah; Edward Rockenstein; Anthony Adame; Michael Alford; Leslie Crews; Makoto Hashimoto; Peter Seubert; Michael Lee; Jason Goldstein; Tamie Chilcote; Dora Games; Dale Schenk
- Book ID
- 116782338
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 774 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0896-6273
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The letter by Papapetropoulos and colleagues presents an additional study correlating ␣-synuclein expression levels and sporadic PD. Previously we and others published studies of mRNA levels of SNCA in PD brains that have been performed using different methods. Some are in agreement with our results
## Abstract Parkinson's disease (PD) is characterized by loss of nigral dopaminergic (DAergic) neurons and presence of Lewy bodies, whose major component is α‐synuclein. We had previously generated transgenic mice termed __Syn130m__ that express truncated human α‐synuclein (amino acid residues 1–13